在免疫检查点抑制剂治疗期间肠道微生物组合的波动
Joy Sarkar1,2, Eduardo Cortes Gomez3,4,2, Takaaki Oba5,6
1Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
在抗PD-1治疗期间肠道微生物群多样性的变化可以预测非小细胞肺癌的反应. 这项试点研究表明,肠道微生物群的动态可以作为ICI治疗有效性的非侵入性生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 微生物组研究的研究.
背景情况:
- 免疫检查点抑制剂 (ICI) 改善非小细胞肺癌 (NSCLC) 的结果,但面临耐药性和有限的预测生物标志物.
- 治疗前瘤PD-L1表达对ICI治疗反应的预测价值有限.
- 需要更少的侵入性生物标志物来识别早期响应者和非响应者,以优化治疗方案.
研究的目的:
- 在NSCLC患者的抗PD-1治疗期间调查肠道微生物组合的变化.
- 为了确定肠道微生物组的动态是否与对抗PD-1免疫疗法的反应相关.
- 探索肠道微生物群作为ICI治疗的非侵入性生物标志物的潜力.
主要方法:
- 从接受抗PD-1免疫治疗的5名NSCLC患者的治疗前和治疗期间便样本的分析.
- 16S rRNA测序以分析肠道微生物组合.
- 响应者与非响应者之间的微生物群多样性和丰度的比较.
主要成果:
- 基线肠道微生物组α多样性在反应者和非反应者之间是相似的.
- 响应者从治疗前到治疗后的肠道微生物群多样性呈现出显著的变化,与非响应者不同.
- 特定的细菌系在治疗期间显示了响应者与非响应者的不同丰度变化.
结论:
- 在治疗前和治疗期间样本之间的肠道微生物群多样性动态区分了接受抗PD-1治疗的NSCLC患者的响应者和非响应者.
- 肠道微生物群的动态显示出作为预测PD-1/PD-L1阻塞治疗反应的非侵入性生物标志物的潜力.
- 需要进一步的前性研究来验证这些发现在更大的患者队列中.
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