在认知障碍患者中,肠道微生物群和肠道屏障功能:一个横截面研究
Ying Pei1,2, Yan Lu2, HuiZi Li3
1Postgraduate Union Training Base of Jinzhou Medical University, PLA Rocket Force Characteristic Medical Center, Beijing, China.
Frontiers in aging neuroscience
|June 23, 2023
概括
阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 中的认知障碍与肠道微生物变化和肠道屏障减弱有关. 这些肠-大脑轴的干扰可能会导致认知能力下降.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠-大脑轴因其在阿尔茨海默氏症 (AD) 等疾病相关的认知障碍中的作用越来越被认可.
- 了解肠道微生物群,肠道屏障功能和认知健康之间的相互作用对于开发新型治疗策略至关重要.
研究的目的:
- 研究患有AD,轻度认知障碍 (MCI) 和正常对照 (NC) 患者的肠道微生物组成,肠道屏障功能和全身炎症的差异.
主要方法:
- 118名受试者 (45名AD,38名MCI,35名NC) 接受了认知和功能评估 (MMSE,MoCA,ADL).
- 用16SrRNA测序分析了肠道微生物组的组成,通过PICRUSt.进行功能预测.
- 通过测量二胺氧化酶 (DAO),D-乳酸 (DA) 和内毒素 (ET) 水平来评估肠道屏障功能障碍.
主要成果:
- 与对照人群相比,认知障碍患者 (AD/MCI) 的*Dorea*含量较低,DAO,DA和ET水平较高.
- 在KEGG路径分析中,MCI患者的糖甘生物合成/代谢增加和膜运输减少.
- *细菌体*和*Faecalibacterium*的丰度与ET负相关,与认知评分 (MMSE,MoCA) 有正相关.
- 肠道屏障功能障碍的严重程度与认知功能有显著的负相关.
结论:
- 肠道微生物失调症和肠道屏障功能障碍与认知障碍有关.
- 这些发现凸显了肠-大脑轴作为AD和MCI认知衰退病原发生的潜在因素.
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