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相关概念视频

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

659
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Immunoprecipitation01:20

Immunoprecipitation

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Immunoprecipitation, or IP, is a widely used technique that employs protein-antibody interactions to isolate proteins or protein complexes in their native state for studying protein-protein interactions, quaternary structures, or supramolecular complexes. Various modifications of the technique, including chromatin IP, cross-linking IP, and fluorescence IP, are commonly used.
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...
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Antibody Actions01:26

Antibody Actions

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
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相关实验视频

Updated: Jul 26, 2025

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
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Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

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序列定义的抗体招募大分子.

Resat Aksakal1, Corentin Tonneaux2, Annemiek Uvyn3

  • 1Polymer Chemistry Research Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Faculty of Sciences, Ghent University 9000 Ghent Belgium nezha.badi@ugent.be filip.duprez@ugent.be.

Chemical science
|June 23, 2023
PubMed
概括
此摘要是机器生成的。

新型抗体招募分子利用序列定义的大分子来增强治疗剂的设计. 这些分子表现出增加的结合力,为开发新的抗体招募疗法提供了洞察力.

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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

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相关实验视频

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Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
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科学领域:

  • 生物技术是生物技术.
  • 免疫学 免疫学 免疫学
  • 材料科学 材料科学 材料科学

背景情况:

  • 抗体招募分子 (ARM) 是一种新的治疗类,可以利用免疫系统消除细胞.
  • 具有多个抗体结合连接体的宏分子支架与单连接体系统相比,提供了优越的性.

研究的目的:

  • 为了合成序列定义的宏分子用于抗体招募.
  • 为了研究连接体间距对抗体结合力的影响.
  • 探索用于设计新型ARM的结构-活动关系.

主要方法:

  • 使用固体相 thiolactone 化学合成序列定义的寡合物.
  • 将丁烯醇 (DNP) 纳入作为一种模型抗体招募动机.
  • 生物层干涉测量和分子建模用于结合分析和结构洞察.

主要成果:

  • 具有相邻DNP动机的寡合体对抗DNP抗体有显著增强的嗜好.
  • 在宏分子脊柱上变化的DNP图案间距影响了结合相互作用.
  • 分子建模阐明了连接物可访问性和宏分子动力学.

结论:

  • 序列定义的大分子提供了一个强大的平台来研究ARM中的结构-活性关系.
  • 在宏分子支架上优化连接体呈现可以提高抗体招募效率.
  • 这些发现为下一代抗体招募疗法的合理设计提供了宝贵的见解.