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Updated: Jul 26, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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线粒体ROS和除基的修复步骤导致DNA形成驱动紫外线诱导的NETosis

Dhia Azzouz1,2, Nades Palaniyar1,2,3

  • 1Translational Medicine, Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.

Frontiers in immunology
|June 23, 2023
PubMed
概括

紫外线 (UV) 辐射会导致线粒体的活性氧物种 (ROS) 损伤DNA,通过DNA修复途径启动中性粒体细胞外陷形成 (NETosis). 这揭示了一种独立于NADPH氧化酶的UV诱导NETosis的新机制.

关键词:
DNA 号形成的形成紫外线辐射的辐射基本排泄修复 (BER) 的基础染色体脱凝的过程中,染色体的脱凝.线粒体中的ROS (线粒体中的ROS) (mitoROS)中性细胞细胞外陷的形成.氧化了DNA的氧化过程.

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