形眼药对近视进展的预防作用:双盲随机临床试验
Abdolreza Medghalchi1, Hasan Behboudi1, Mitra Akbari1
1Department of Eye, Eye Research Center, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
International journal of preventive medicine
|June 23, 2023
概括
形眼液有效地减缓了儿童近视的进展. 然而,在停止治疗后会出现反弹效应,这表明较低的剂量可能会减少副作用和反弹进展.
科学领域:
- 眼科医生 眼科 眼科
- 儿科医学 儿科医学
- 临床试验 临床试验
背景情况:
- 近视的进展是儿童和青少年的一个重大问题.
- 对近视控制的有效干预措施的调查至关重要.
研究的目的:
- 评估与安慰剂相比,两种不同剂量的阿特罗宾眼药在减缓近视进展方面的疗效.
- 评估与阿特罗宾治疗相关的安全性和副作用.
主要方法:
- 一个双盲,随机的临床试验,涉及67名6-18岁的近视患者.
- 参与者每晚接受安慰剂,0.01%的氨酸或0.1%的氨酸眼滴,持续六个月.
- 测量包括球体等价,轴长,视力敏度和一年的随访期间的副作用.
主要成果:
- 六个月后,与安慰剂相比,阿特罗宾组在球体等价,轴长和远视敏度方面表现出更大的改善.
- 光恐惧症和近视敏度下降是0.1%的阿特罗宾的常见副作用.
- 在停止治疗六个月后,观察到近视进展的显著反弹效应,特别是在0.1%的阿特罗平组.
结论:
- 阿特罗平眼滴在抑制近视的进展方面表现出有效性.
- 停止氨酸治疗可能会导致反弹效应.
- 建议使用较低度的阿特罗宾 (0.01%),以尽量减少副作用和反弹进展.
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