尼古丁替代疗法在肺结核患者中戒烟和减少吸烟的有效性 - 随机对照试验
Jagannath Purushothama1, Sanjeev Badiger2, Jeby J Olickal1
1Department of Public Health, K S Hegde Medical Academy, Nitte (Deemed to be University), Mangaluru, Karnataka, India.
International journal of preventive medicine
|June 23, 2023
概括
尼古丁替代疗法 (NRT) 在结核病患者中显著降低了自我报告的吸烟. 虽然NRT有助于减少吸烟,但在本研究中,它没有显著增加生化验证的吸烟戒断率.
科学领域:
- 公共卫生 公共卫生
- 临床干预 临床干预
- 控制烟草的控制方式
背景情况:
- 印度面临着高烟草使用和结核病 (TB) 流行的双重负担.
- 吸烟对结核病治疗结果产生负面影响,需要有效的戒烟干预措施.
- 解决结核病患者的烟草使用问题对于打击共同流行病至关重要.
研究的目的:
- 评估尼古丁替代疗法 (NRT) 对肺结核患者吸烟减少和戒烟的有效性.
- 评估NRT与结核病患者吸烟行为的简短建议相结合的影响.
主要方法:
- 一项为期6个月的随机对照试验,涉及印度300名肺结核患者.
- 参与者接受了简短的建议加NRT (实验组) 或简短的建议加安慰剂 (对照组).
- 结果包括自我报告的吸烟减少和生物化学验证的戒烟,使用相对风险和回归来分析.
主要成果:
- 在NRT组显示,自我报告的吸烟率显著下降 (ARR=1.08,P=0.03).
- 在NRT和安慰剂组之间没有观察到生物化学验证的吸烟戒断的显著差异 (ARR = 1.01,P=0.97).
结论:
- 尼古丁替代疗法 (NRT) 在减少结核病患者自我报告的吸烟方面显示出统计学上显著的有效性.
- 可能需要进一步的研究来提高通过生物化学措施验证的戒烟率.
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