双S对氧化应激和生殖系统内分泌生物标志物的影响:系统性审查和元分析
Beheshteh Abouhamzeh1, Zohreh Zare2, Moslem Mohammadi3
1Alireza Nourian Department of Anatomical Sciences, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
International journal of preventive medicine
|June 23, 2023
概括
双-S (BPS) 暴露与生殖系统损伤有关,增加氧化应激和破坏男性和女性的激素水平. 这一元分析表明,BPS对生殖健康构成重大风险.
科学领域:
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
背景情况:
- 双-S (BPS) 被用作塑料中无双-A (BPA) 的替代品,引发了公众健康问题.
- 新兴研究表明BPS的潜在不良影响,需要对其对生殖系统的影响进行全面审查.
研究的目的:
- 系统地审查和对现有研究进行元分析,研究双-S (BPS) 暴露与生殖系统功能障碍之间的关系.
- 评估BPS对氧化应激标志物和男性和女性受试者生殖激素水平的影响.
主要方法:
- 在PubMed和其他数据库中进行了系统的文献搜索,截至2021年1月.
- 使用随机效应模型计算标准平均差异 (SMD),主要参数的 95% 置信区间 (CI).
- 包括12项涉及420名受试者的研究,分析包括森林地块,元回归和非线性剂量反应效应.
主要成果:
- 暴露于BPS显著增加了氧化应激标志物,包括超氧化脱酶,硫酸反应物质和反应性氧物种.
- 激素评估显示,男性丸激素水平显著下降.
- 在体内检查显示,女性丸激素,雌激素,白质化激素和卵泡刺激激素 (FSH) 的显著降低.
结论:
- 这一元分析表明,双-S (BPS) 对生殖系统有毒,反映了其他双的作用.
- 表明BPS诱导的氧化应激和激素干扰之间存在相关性,这有助于两性繁殖系统的乱/功能障碍.
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