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诊断时的单细胞作为结核患者患有贫血的预后生物标志物

Mengxing Luo^1,2, Xin Zou^1,2, Qibing Zeng²

¹Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Frontiers in medicine

|June 23, 2023

概括

单细胞数量升高预示着贫血结核病患者 (A-TB) 的预后不佳和腔腔关闭延迟. 单细胞可以作为A-TB的简单预后生物标志物,有助于预测治疗结果.

科学领域:

免疫学免疫学免疫学
肺部病理学肺部病理学
临床医学临床医学

背景情况:

贫血使结核病 (TB) 治疗复杂化,导致治愈率降低,预后更差.
鉴定结核病 (A-TB) 患者贫血的可靠预后生物标志物对于有效管理至关重要.
单细胞,关键的先天性免疫细胞,与肺部疾病有关,但它们在A-TB的预后作用尚不清楚.

研究的目的:

研究结核病和贫血 (A-TB) 患者单细胞的预后价值.
确定单细胞水平是否可以预测A-TB患者的治疗结果和腔腔闭合.

主要方法:

在上海肺部医院接受治疗的A-TB患者的回顾性分析.
后勤回归和Cox比例危险模型来评估外围血液细胞和预后之间的关联.
接收器操作特征 (ROC) 曲线分析,以确定单细胞的最佳切断值.
卡普兰-梅尔分析估计12个月治愈率.

主要成果:

单细胞计数被确定为A-TB预后的独立免疫相关风险因素 (OR:7.881,P=0.009).
通过ROC分析确定了0.535 × 10 ^ 9 / L的最佳单细胞切断值.
单细胞计数<0.535×10^9/L的A-TB患者的治愈率 (69.62%) 与计数≥0.535×10^9/L (38.24%) (P<0.0001) 的患者相比显著更高.
在A-TB患者中,单细胞升高独立预测肺腔闭合不良 (HR: 3.614,P=0.011).

结论:

在A-TB患者中,单细胞水平升高与预后不佳和肺腔关闭延迟有关.
单细胞计数是一种简单,廉价和有价值的A-TB预后生物标志物.

关键词:

贫血贫血是一种疾病.生物标志物生物标志物一个单细胞单细胞.预后预后预后结核病是一种肺结核病.

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