咖啡消费对甲状腺功能的影响:NHANES 2007-2012和孟德尔随机化
Guoxu Zhao1, Zhao Wang2, Jinli Ji1
1Mudanjiang Medical University, Mudanjiang, China.
Frontiers in endocrinology
|June 23, 2023
概括
喝咖啡可能有益于甲状腺健康. 适度咖啡摄入量 (每天少于2杯) 与降低亚临床甲状腺功能低下风险有关,而每天2至4杯咖啡可能会降低TSH水平. 咖啡没有影响甲状腺功能过高或甲状腺功能低下的风险.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 咖啡是全球流行的饮料,对甲状腺功能的影响基本未知.
- 甲状腺疾病,包括甲状腺功能低下症和甲状腺功能过高症,影响全球数百万人.
- 了解饮食对甲状腺健康的影响对于公众健康至关重要.
研究的目的:
- 调查咖啡消费与甲状腺功能标志物之间的关联.
- 为了确定咖啡摄入是否影响亚临床甲状腺功能低下症的风险.
- 探索咖啡和明显的甲状腺功能障碍或甲状腺功能障碍之间的关系.
主要方法:
- 从NHANES 2007-2012中利用了来自6,578名成年人 (≥20岁) 的数据进行观测分析.
- 采用加权线性和逻辑回归模型来分析关联.
- 使用来自IEU数据库 (462,933个欧洲样本) 的遗传数据进行了门德尔随机化 (MR),并进行了逆方差加权 (IVW).
主要成果:
- 每天摄入2-4杯咖啡与显著降低TSH度相关 (b=-0.23).
- 每天摄入少于2杯咖啡,可以降低亚临床甲状腺功能低下的风险 (OR=0.60).
- 没有发现咖啡消费与甲状腺功能增强症或甲状腺功能低下症风险之间的统计学意义上的关联.
结论:
- 较低的咖啡消费 (每天少于2杯) 可能会降低亚临床甲状腺功能低下的风险.
- 适度咖啡摄入量 (每天2-4杯) 与降低的TSH水平有关.
- 咖啡消费似乎与甲状腺功能障碍和甲状腺功能低下的风险无关.
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