外周线粒体DNA水平对COVID-19疫苗接种后免疫反应的影响
Hiroaki Ikezaki1,2,3, Hideyuki Nomura3, Nobuyuki Shimono1
1Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 8128582, Japan.
iScience
|June 23, 2023
概括
线粒体DNA (mtDNA) 水平与老年人疫苗诱导的免疫反应具有积极的相关性. 更高的mtDNA水平与更强的抗体标位和细胞介导免疫有关,这表明它在抗击免疫发生方面发挥了作用.
科学领域:
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
- 分子生物学分子生物学
背景情况:
- 在老年人中,疫苗对SARS-CoV-2的疗效因免疫衰变而降低.
- 线粒体DNA (mtDNA) 水平下降与免疫发生有关.
- 了解影响老年人接种疫苗反应的因素至关重要.
研究的目的:
- 评估外围白细胞mtDNA水平与对SARS-CoV-2疫苗接种的免疫反应之间的相关性.
- 为了比较疫苗接种后脆弱与强壮的老年人免疫反应.
主要方法:
- 在210名老年参与者 (平均年龄79.5岁) 中,从疫苗接种前到第三剂后,对抗尖峰IgG抗体 (IgG(S)) 标位的连续测量.
- 测量第三次接种疫苗后参与者的子组中mtDNA水平和细胞介导免疫力.
- 将参与者分为脆弱 (住院/住院患者) 和强壮 (门诊患者) 组.
主要成果:
- 健壮的老年参与者与脆弱的参与者相比,IgG(S) 标位始终较高.
- mtDNA水平与IgG(S) 标位和细胞介导免疫力都有正相关性.
- 这些发现突显了mtDNA数量与疫苗有效性之间的联系.
结论:
- 在老年人中,mtDNA水平似乎对疫苗诱导的免疫力产生了积极的影响.
- 维持mtDNA水平可能是缓解免疫衰变的潜在策略.
- 需要进一步研究mtDNA在衰老和免疫力中的作用.
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