乳酸可以通过微生物组-肠-大脑轴缓解西方饮食引起的认知障碍
Qian He1, Li-Li Zhang1, Deming Li1
1Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu, 215123, China.
Current research in food science
|June 23, 2023
概括
乳酸 (Lf) 补充剂通过减少神经炎症和增强突触结构,改善了小鼠的认知功能. 通过微生物群-肠-大脑轴的肠道微生物群调节对乳酸铁素至关重要.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 乳酸 (Lf) 在动物模型中显示出对认知增强的承诺.
- 连接Lf,肠道微生物群和大脑功能的机制需要阐明.
研究的目的:
- 研究Lf对认知功能及其潜在机制的影响.
- 探索肠道微生物群在Lf的认知效益中的作用.
主要方法:
- 雄性C57BL/6J小鼠接受了16周的对照,西方饮食,Lf或Lf +抗生素干预.
- 通过行为测试来评估认知功能.
- 分析了海马突触可塑性,神经炎症 (小质,细胞因子,NF-κB/NLRP3炎症体),肠道微生物群组成和紧密结合蛋白.
主要成果:
- Lf改善了认知功能,增加了突触后密度的长度/曲率,并上调相关蛋白质.
- Lf抑制了微质激活,减少了促炎细胞因子,并抑制了海马NF-κB/NLRP3炎症酶.
- 通过调节紧密结蛋白和增加有益细菌 (Bacteroidetes,Roseburia) 来增强肠道屏障的完整性.
- 抗生素抵消了Lf的认知效益,证实了肠道微生物群的参与.
- 短期Lf阻止了西方饮食诱导的肠道微生物群变化,而不会影响行为,突出了肠道至大脑的时间表.
结论:
- 乳二烯通过调节微生物组-肠-大脑轴来缓解认知障碍.
- 通过减少神经炎症和增强突触可塑性,Lf具有神经保护作用.
- 肠道微生物群在调解乳酸的认知益处方面发挥着至关重要的作用.
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