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[光检测诊断黑色素瘤:一种皮肤组织学替代客观方法]

Dieter Leupold¹

¹vormals LTB Lasertechnik Berlin GmbH, Am Studio 2c, 12489, Berlin, Deutschland. dieter.e.leupold@web.de.

Dermatologie (Heidelberg, Germany)

|June 23, 2023

概括

皮肤组织光学通过分析黑色素光谱来提供一种客观的黑色素瘤诊断方法. 这项技术将黑色素瘤细胞与良性瘤细胞区分开来,提高了具有挑战性的病例的诊断准确性.

科学领域:

皮肤病学皮肤病学
在瘤学瘤学.
医学诊断医学诊断医学诊断
频谱学是一种光谱学.

背景情况:

黑色素瘤诊断传统上依赖于皮肤组织学评估,这是一种主观的方法,取决于检查人员的专业知识.
目前的诊断方法的主观性质需要开发更客观和可靠的技术.

研究的目的:

引入和评估皮肤透透镜作为一种新的客观方法,以提高黑色素瘤诊断可靠性.
提高黑色素瘤诊断的准确性,特别是在具有挑战性的病例中,如Spitzoid瘤.

主要方法:

利用颜色载体皮肤细胞中的黑色素的超弱,光谱分辨的光,作为恶性瘤指标.
采用专门的激光光谱法,在组织学样本和组织上测量黑色素光.
分析黑色素细胞,新黑色素细胞和黑色素瘤细胞发出的特征性光光谱.

主要成果:

从正常颜色的皮肤中发现的黑色素细胞,来自良性/异形瘤细胞的新型黑色素细胞和黑色素瘤细胞的显著光光谱.
这些细胞类型的不同颜色的空间分辨率为组织病理学诊断提供了客观的基础.
400纳米的二次信号识别了瘤穿过底层膜的突破,甚至适用于美肌性黑色素瘤.

结论:

皮肤基光学为黑色素瘤提供了客观的诊断标准,在困难的情况下提供了帮助,并减少了主观性.
该方法目前仅限于菲茨帕特里克1型和2型皮肤,但对更广泛的应用有希望.
400纳米的原结合信号扩展了对乳腺性黑色素瘤的适用性,检测了底层膜入侵.

关键词:

在皮肤上进行光镜检查 (dermatohistofluoroscopy).诊断可靠性诊断的可靠性异常的瘤位置异常的瘤位置.页面形状的分布是页面形状的.尖子状神经瘤和瘤.

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