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增强的线粒体G-四重复形成阻碍了复制叉的进展,导致人类细胞中的mtDNA损失

Mara Doimo1,2, Namrata Chaudhari1, Sanna Abrahamsson3

  • 1Department of Medical Biochemistry and Biophysics, Umeå University, 90187 Umeå, Sweden.

Nucleic acids research
|June 23, 2023
PubMed
概括

线粒体DNA (mtDNA) 复制停滞增加G-四重复 (G4) 形成,这可能导致mtDNA删除. 未解决的G4s会对mtDNA完整性产生负面影响,导致衰老和遗传性疾病.

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