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Updated: Jul 25, 2025

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
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Published on: November 10, 2016

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金属稳定了DNA三向结点,并诱导癌细胞中的DNA损伤

Jaroslav Malina1, Hana Kostrhunova1, Peter Scott2

  • 1Czech Academy of Sciences, Institute of Biophysics, Brno, CZ-61200, Czech Republic.

Nucleic acids research
|June 23, 2023
PubMed
概括

基于铁的金属元素有效地结合和稳定DNA三向结 (3WJ),这是DNA修复的关键中间体. 这些化合物还会诱导DNA损伤,显示出癌症治疗的潜力.

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