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肯尼亚年轻妇女在暴露前预防 (PrEP) 多重依从措施的表现

Nicholas Musinguzi¹, Kenneth Ngure^2,3, Elizabeth A Bukusi^4,5,6

¹Global Health Collaborative, Mbarara University of Science and Technology, Mbarara, Uganda. nmusinguzi@gmail.com.

AIDS and behavior

|June 23, 2023

概括

准确测量暴露前预防 (PrEP) 坚持是预防艾滋病毒的关键. 这项研究发现,电子监测和TFV-DP血液测试是肯尼亚年轻女性有效的依从工具.

科学领域:

公共卫生公共卫生
药理学药理学是指药理学的学科.
生物医学科学生物医学科学

背景情况:

了解对暴露前预防 (PrEP) 的遵守对于有效的艾滋病毒预防策略至关重要.
在现实环境中,精确测量PrEP的坚持存在重大挑战.

研究的目的:

在肯尼亚的年轻女性中,比较PrEP的多重遵守措施的一致性和性能.
评估电子粘附监测 (EAM) 和干血斑点中的二酸 (TFV-DP) 与自我报告的措施相比.

主要方法:

一项为期两年的研究涉及289名肯尼亚年轻女性,她们面临高风险感染艾滋病毒.
电子粘附监测 (EAM) 的粘附数据的比较,在干燥的血液斑点中测定二酸 (TFV-DP),以及自我报告的措施.
统计分析包括一致率,接收器运行曲线下的面积 (AUC) 和相关系数.

主要成果:

EAM和TFV-DP之间的一致性在57%-72%之间.
TFV-DP显示EAM具有很高的歧视 (AUC0.85),而自我报告的措施具有很低的歧视 (AUC0.49-0.54).
在EAM和自我报告的措施之间观察到较低的相关性 (r < 0.11),但在自我报告的措施中存在温和的相关性 (r > 0.69).

结论:

无论是TFV-DP还是EAM都是评估高风险人群对PrEP的遵守的有价值的工具.
需要提高这些测量工具的可访问性和可负担性.
需要对TFV-DP值进行进一步的研究,以优化其用于PrEP遵守监测的解释.

关键词:

坚持的坚持坚持的坚持青少年青少年青少年非洲非洲非洲在 DBS 中,DBS 是 DBS 的代名词.这就是为什么PrEP是PrEP.在TFV-DP中使用.女人女人女人女人女人

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