我们可以从慢性暴露的流行病学研究中学到什么?
Yalçın Duydu1, Nurşen Başaran2, Hermann M Bolt3
1Department of Toxicology, Faculty of Pharmacy, Ankara University, Ankara, Türkiye.
Critical reviews in toxicology
|June 23, 2023
概括
在中国和土耳其,高职业暴露没有导致生殖或发育影响. 人类目前的血水平不太可能达到危险的临界值,即使在日常生活中也会产生不良影响.
科学领域:
- 环境毒理学环境毒理学
- 生殖毒理学 生殖毒理学
- 职业健康 职业健康 职业健康
背景情况:
- 酸和酸盐被归类为对生殖和发育有毒的物质 (EU-CLP类别1B,H360FD).
- 这种分类促使人们对中国,土耳其和阿根廷的暴露进行流行病学研究.
研究的目的:
- 调查暴露在职业环境中的生殖和发育影响.
- 将人类暴露水平与已确定的参考剂量 (RfDs) 和没有观察到不良影响水平 (NOAELs) 进行比较.
主要方法:
- 中国和土耳其的流行病学研究评估了每日总暴露 (DBE) 和血度.
- 观察到的人类暴露和血液水平与动物研究的NOAEL和拟议的人类RfD的比较.
主要成果:
- 在职业环境中最高的DBE平均水平超过了针对发育和生殖效应的建议RfD.
- 尽管暴露量很高,但在人类研究中没有报告介导的生殖或发育影响.
- 观察到的血度明显低于动物模型中与不良影响相关的度.
结论:
- 人类目前的职业和可能的日常生活中的暴露水平似乎不会导致生殖或发育损害.
- 对的生殖和发育毒性的风险评估可能需要根据人类流行病学数据重新评估.
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