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18F-fluorodeoxyglucose摄入量与皮肤生长因子受体在鼻腔癌中的突变状态之间的关联

Hidenori Suzuki¹, Eiichi Sasaki², Tsuneo Tamaki³

¹Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan; hi.suzuki@aichi-cc.jp.

Anticancer research

|June 23, 2023

概括

18F-FDG-PET/CT不能预测皮肤生长因子受体 (EGFR) 突变状态在鼻道状细胞癌 (STSCC). 然而,PET/CT上代谢性瘤体积增加与STSCC患者的生存结果较差有关.

科学领域:

在瘤学瘤学.
核医学是一种核医学.
分子成像学分子成像学

背景情况:

沃伯格效应,其特点是增加18F-氧葡萄糖 (18F-FDG) 的吸收,是癌症代谢的标志.
18F-FDG正子发射断层扫描与计算机断层扫描 (PET/CT) 用于癌症检测和分期.
以前的研究表明,18F-FDG-PET/CT可以预测肺癌中的EGFR突变状态.

研究的目的:

确定18F-FDG吸收参数是否与鼻道状细胞癌 (STSCC) 中的EGFR突变状态相关.
在STSCC中探索18F-FDG吸收参数的预后价值.

主要方法:

对29个STSCC原发性瘤样本的分析.
使用曼·惠特尼U测试和受体操作曲线分析,比较EGFR突变和野生型瘤之间的18F-FDG吸收.
使用单变量和多变量模型,根据临床阶段,治疗和EGFR状态进行调整的生存分析 (STSCC特异性,无疾病,无局部复发).

主要成果:

在EGFR突变和野生型STSCC瘤之间没有观察到18F-FDG吸收的显著差异.
代谢性瘤体积 (MTV) ≥25显着与较短的STSCC特异性,无疾病和局部无复发的生存时间相关.
MTV的预后价值独立于临床阶段,治疗和EGFR状态.

结论:

18F-FDG-PET/CT成像不是在STSCC中EGFR突变状态的可靠预测器.
通过18F-FDG-PET/CT评估的代谢性瘤体积增加是STSCC患者生存的显著负预后因素.

关键词:

18F-化氧葡萄糖的摄取量代谢性瘤的体积和体积.表皮生长因子受体的突变状态.其他鼻道.状细胞癌 (SCLC) 是一种状细胞癌.

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