禁食体和发生2型糖尿病的一般人口
Tamas Szili-Torok1, Martin H de Borst1, Erwin Garcia2
1Department of Internal Medicine, University Medical Center Groningen, Groningen, the Netherlands.
禁食的体,包括3-β-酸和酸+酸,与患2型糖尿病的更高风险密切相关. 这一发现对糖尿病预防策略和识别新的生物标志物具有重要意义.
科学领域:
- 代谢研究的研究.
- 发现生物标志物的发现.
- 流行病学 流行病学
背景情况:
- 2型糖尿病的发病率上升需要新的预防策略.
- 体正在成为潜在的生物标志物,但关于它们与糖尿病风险的联系的数据有限.
研究的目的:
- 调查空腹体水平与一般人群中2型糖尿病的发病率之间的联系.
主要方法:
- 这是一项针对PREVEND队列中的3307名参与者进行的前性研究,最初没有糖尿病.
- 用核磁共振光谱学测量的禁食体度 (3-β-基酸盐,乙酸盐+乙).
- 对发生的2型糖尿病的随访时间平均为7.3年,使用卡普兰-梅尔和考克斯回归分析.
主要成果:
- 126名参与者 (3.8%) 患有2型糖尿病.
- 更高的禁食类体水平与发生的2型糖尿病有着强烈的积极关联.
- 经过调整混因素后,关联仍然显著,并且在两性之间一致.
结论:
- 禁食等离子体是一般人群中发生2型糖尿病的显著积极预测因素.
- 这些发现支持体作为糖尿病风险的潜在生物标志物的作用.
- 结果对糖尿病预防有影响,包括饮食干预措施.
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