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Updated: Jul 25, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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立体选择性分子内 [2+2] 1,2-环二基因的捕获:通往刚性,角融合三环架的途径

Christian L Jankovic1, Kyle C McIntosh1, Verner A Lofstrand1

  • 1Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.

Chemistry (Weinheim an der Bergstrasse, Germany)
|June 23, 2023
PubMed
概括

化物介导的脱生成1,2-环二,这些二有效地经历了分子内 [2+2] 捕获. 这种反应产生 cis 融合的三环基基烯环素,具有高二选择性和高达 91% 的产量.

关键词:
[2+2] 这里有两个字.循环的艾伦基因.循环添加物循环添加物循环butanes 的使用情况.这是一种立体选择式的选择.

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