层心肌菌株是最可遗传的心声回声学特征
Olivier Huttin1,2, Constance Xhaard1, Claire Dandine-Roulland3
1Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France.
全球纵向子内心/心下压力比率显示出高遗传性,这表明遗传因素影响心脏力学. 其他心脏功能指数的遗传性较小,大部分变化归因于环境因素.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 医疗成像医学成像
背景情况:
- 心肌应变分析对于评估心脏机制至关重要.
- 心脏力学指数的遗传性在很大程度上是未知的.
- 了解遗传与环境影响的对比是个性化医学的关键.
研究的目的:
- 为了确定心声学确定心脏力学指数的遗传性.
- 为了研究对心肌功能变异性的遗传贡献.
- 为了评估层特异性心肌菌株的遗传性.
主要方法:
- 从纵向的斯坦尼斯拉斯队列中对1357名健康受试者的分析.
- 使用最先进的心脏超声波和EACVI/ASE协议.
- 使用限制最大概率分析和全基因组关联数据评估遗传性.
主要成果:
- 全球纵向应变和射出分数的低遗传性 (10-20%).
- 适度遗传性 (20-30%) 对于透析和标准LV功能参数.
- 高遗传性 (65%) 对于全球纵向子内心/心下支柱应变比.
结论:
- 全球纵向子内心/心下压力比率是高度遗传的.
- 其他心脏功能参数显示遗传能力有限.
- 表明潜在的遗传倾向心肌衰退,突出GLSEndo/GLSEpi比率作为生物标志物.
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