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镜像内动脉瘤的破裂风险因素:基于形态和血液动力学参数的系统审查和元分析
Huang Yong-Wei1, Xiao-Yi Wang1, Zong-Ping Li1
1Department of Neurosurgery, Mian yang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mian yang, Sichuan, People's Republic of China.
PloS one
|June 23, 2023
概括
镜像内动脉瘤 (MIA) 存在破裂的风险. 较大的尺寸,尺寸比,尺寸比和不规则的形状增加了MIA破裂的风险,而破裂和未破裂病例之间的高度宽度比没有显著差异.
科学领域:
- 血管神经学 血管神经学
- 医疗成像医学成像
- 生物医学工程 生物医学工程
背景情况:
- 内动脉瘤 (IAs) 是一种常见的血管疾病,其结果可能是致命的.
- 镜像内动脉瘤 (MIA) 是对称的IA,它们破裂的危险因素也在讨论中.
- 了解MIA破裂风险因素对于临床管理至关重要.
研究的目的:
- 系统地审查和元分析与MIA破裂风险相关的形态和血液动力学参数.
- 为了澄清导致MIA破裂的有争议的因素.
主要方法:
- 对18项遵循PRISMA指导方针的回顾性研究进行了系统审查和元分析.
- 分析形态参数 (IA大小,视角比 [AR],尺寸比 [SR],瓶因子 [BNF],高度宽度比 [HWR],不规则形状) 和血液动力参数 (墙壁剪切应力 [WSS],低WSS区域 [LSA],振荡剪切指数 [OSI]).
主要成果:
- 对647名患者 (1294名IA) 的元分析显示,破裂和未破裂的MIA之间IA大小,AR,SR和不规则形状的显著差异.
- 血液动力学参数WSS,OSI和LSA也显示出显著的差异.
- HWR在破裂和未破裂组之间没有显著差异.
结论:
- 更大的IA大小,更高的AR,SR和BNF与增加MIA破裂风险有关.
- 血动力学因素如WSS,OSI和LSA是破裂风险的重要指标.
- 需要进一步的多中心研究来验证这些发现,以改善临床决策.
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