作为慢性疼痛的危险因素的COVID-19症状负荷:一项全国横截面研究
Jamie L Romeiser1, Christopher P Morley1, Sunitha M Singh2,3
1Department of Public Health and Preventive Medicine, Upstate Medical University, Syracuse, New York, United States of America.
PloS one
|June 23, 2023
概括
严重的COVID-19感染可能会增加患慢性疼痛的风险. 这项研究发现,与未感染的个人相比,中度至严重的COVID-19症状的个体患疼痛的几率更高.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 疼痛医学 医学 疼痛医学
背景情况:
- 新出现的证据将严重的COVID-19与慢性疼痛等长期COVID疾病联系起来.
- 作为慢性疼痛的风险因素的COVID-19感染严重程度的作用尚未得到充分证实.
- 慢性疼痛的传统风险因素无法解释潜在的COVID-19影响.
研究的目的:
- 调查COVID-19感染严重程度是否是慢性疼痛的新风险因素.
- 为了比较不同COVID-19症状严重程度的个体中慢性疼痛的几率.
- 评估中度/重度COVID-19症状与慢性疼痛患病率之间的关联.
主要方法:
- 分析了2021年国家健康访谈调查数据 (n=15,335).
- 根据COVID-19症状严重程度 (没有/轻度与中度/重度) 和感染状态 (从未感染) 检查过去3个月中高频度疼痛的概率.
- 使用1:1:1的倾向分数匹配进行强大的比较.
主要成果:
- 在中度/重度COVID-19症状组 (25.48%) 与没有感染组 (19.44%) 的疼痛患病率显著更高.
- 调整后的模型显示,中度/高度COVID-19症状组的疼痛概率增加 (OR=1.28,CI=1.09-1.51).
- 倾向性得分匹配分析证实疼痛的几率更高 (OR=1.45,CI=1.14-1.83).
结论:
- 中度至高度症状的COVID-19感染可能代表慢性疼痛的新风险因素.
- 严重的COVID-19病例的增加可能会导致整体慢性疼痛患病率的增加.
- 预防严重的COVID-19感染在正在进行的长途症状研究中仍然至关重要.
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