使用聚合物纳米凝进行3D光学一致性温度测量
Tamara Muñoz-Ortiz1,2, Idoia Alayeto3, José Lifante4,5
1nanomaterials for BioImaging Group (nanoBIG), Departamento de Física de Materiales, Facultad de Ciencias, Universidad Autónoma de Madrid, C/ Francisco Tomás y Valiente 7, Madrid, 28049, Spain.
Advanced materials (Deerfield Beach, Fla.)
|June 23, 2023
概括
光学连贯温度计 (OCTh) 使用热响应纳米凝和3D成像来实现精确的,最少侵入性的温度映射. 这一突破将纳米热度计推进到潜在的临床应用.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 在光学成像系统中,光学成像
背景情况:
- 纳米热度测量提供了远程,最少的侵入性温度传感,对于生物医学应用至关重要,传统方法失败.
- 目前的纳米热度测量在临床转化方面面临限制,原因是缺乏3D热成像和依赖非标准设备.
研究的目的:
- 开发一种新的纳米温度计技术,克服目前临床翻译的局限性.
- 引入光学一致性温度计 (OCTh) 以同时进行3D热成像和使用临床上可用的工具.
主要方法:
- 结合热敏聚合物纳米凝与光学一致性断层扫描 (OCT),一个标准的3D临床成像模式.
- 使用的纳米凝体积相位过渡诱导的折射率变化作为温度敏感的OCT对比剂.
- 验证了OCTh在经历光热过程的组织幻体中的3D热成像能力,与数值模拟进行比较.
主要成果:
- 演示了OCTh在组织幽灵中产生3D热图像的能力.
- 通过与数值模拟进行比较,证实了OCTh的可靠性和准确性.
- 展示了纳米凝作为有效的温度敏感的OCT对比剂.
结论:
- OCTh成功地克服了3D热成像和纳米热度测量的临床设备要求的障碍.
- 这项技术为在临床环境中实施先进纳米温度计提供了可靠的基础.
- OCTh代表了纳米热度测量用于精确温度监测的临床翻译的重要一步.
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