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早期抗生素治疗失败的定义的基本组成部分:一个范围审查
Hiroyoshi Iwata1,2, Makoto Kaneko3, Takuya Aoki4
1Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
PloS one
|June 23, 2023
概括
定义早期抗生素治疗失败 (EATF) 对于一致的药物有效性评估至关重要. 这次审查确定了EATF定义的五个基本组成部分:死亡率,生命体征,发烧,症状和额外的治疗.
科学领域:
- 传染性疾病 传染性疾病
- 临床药理学 临床药理学
- 证据综合 证据综合
背景情况:
- 全球抗生素使用广泛,但缺乏早期抗生素治疗失败 (EATF) 的标准化定义.
- 这种缺失导致对抗生素有效性和临床治疗评估的评估不一致.
研究的目的:
- 进行范围审查,以确定和综合现有EATF定义中使用的常见组件.
- 建立一个普遍接受的EATF定义的基础.
主要方法:
- 在多个数据库 (PubMed,CENTRAL,CINAHL,Web of Science) 和谷歌进行了系统的文献搜索.
- 遵循PRISMA范围审查指南,包括标题/摘要选,全文审查和使用关键评估技能计划进行质量评估.
- 数据提取的重点是符合条件的研究中EATF定义的时间,组件和细节.
主要成果:
- 该综述分析了61项研究 (56项原始研究,5项综述) 从最初的2,472项研究中.
- 在评估EATF时间的43项研究中,大多数研究在开始服用抗生素72小时后进行了评估.
- 确定了EATF定义的五个基本组成部分:死亡率,生命体征,发烧,症状和需要额外治疗.
结论:
- 这次范围审查确定了五个关键因素,有助于定义早期抗生素治疗失败.
- 建议进行进一步的研究来验证这些已识别的组件,并建立一个强大的EATF定义.
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