自然果的抗菌性质:系统文献综述
Natalia García-Manríquez1, Carla Lozano2, Ana Muñoz1
1Cariology Unit, Department of Oral Rehabilitation, Faculty of Dentistry, University of Talca, Talca, Chile.
葡萄种子提取物和蔓越在预防洞方面表现有前途. 这些果化合物可能有助于重新矿化牙,并减少有害的牙生物膜,为牙损伤管理提供了潜在的新策略.
科学领域:
- 口腔健康 口腔健康
- 自然产品 化学 化学
- 生物化学 生化学
背景情况:
- 水果,特别是果中的多化合物与抗原性质有关.
- 目前尚不清楚果对牙生物膜和牙的抑制作用的证据.
- 在PROSPERO CRD42020223579.9注册的系统审查.
研究的目的:
- 系统地审查和总结关于果的抗癌和牙生物膜抑制作用的科学文献.
- 探索果衍生化合物在牙腐烂预防中的潜力.
主要方法:
- 在PubMed,Web of Science和SCOPUS数据库中进行系统的文献搜索,遵循PRISMA指南.
- 包括23项研究,主要是体外试验,风险评估和数据提取.
- 使用标准化平均差异 (SMD) 进行的元分析,具有95%的置信区间 (CI).
主要成果:
- 葡萄种子提取物 (GSE) 证明牙面膜 (SMD = 0.96) 和牙 (SMD = 0.65) 的再生矿物化得到加强.
- 蔓越提取物显著减少了牙生物膜生物质 (SMD = -2.23) 和生物体积 (SMD = -2.86),同时增加了生物膜pH (SMD = 7.9).
- 据报道,只有GSE,蔓越和酸桃有抗菌作用.
结论:
- 葡萄种子提取物和蔓越,或它们的活性化合物,显示出作为牙腐烂管理的替代策略的潜力.
- 需要进行进一步的临床试验,以在现实世界的临床环境中验证这些发现.
- 这些发现突显了特定果提取物在口腔健康方面的治疗潜力.
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