童年体重指数和牛皮风险之间的偶然关联:孟德尔的随机化研究
Yuan Li1,2, Wei Zhang3,4, Gaihe Chen1
1Department of Dermatology, The Fifth People's Hospital of Hainan Province, Haikou, China.
Journal of cosmetic dermatology
|June 23, 2023
概括
儿童体重指数 (BMI) 增加可能会因果性地增加牛皮风险. 这项门德尔随机化研究表明,儿童BMI较高与患上牛皮的可能性更高之间存在联系.
科学领域:
- 遗传学 遗传学 是一个
- 流行病学 流行病学
- 皮肤病学 皮肤病学
背景情况:
- 观察性研究表明,儿童体重指数 (BMI) 和牛皮风险之间存在联系.
- 儿童BMI和牛皮之间的因果关系尚不清楚.
研究的目的:
- 通过使用孟德尔随机化来调查儿童BMI和患上牛皮的风险之间的潜在因果关系.
主要方法:
- 利用了来自全基因组关联研究 (GWAS) 的儿童BMI (n=39,620) 和牛皮 (n=337,159) 的总结统计数据.
- 采用孟德尔随机化 (MR) 技术,包括逆方差加权 (IVW),加权中位数和MR-Egger回归.
- 仪器变量来自与儿童BMI相关的16个单核酸多态.
主要成果:
- IVW和加权中位数方法表明,儿童BMI较高和牛皮风险增加之间存在因果关系 (分别p=0.006和p=0.029).
- 在MR-Egger回归分析中,没有发现显著的定向变性 (p=0.247),这表明观察到的关联不太可能是由于偏差.
- 科克兰的Q测试和漏斗图表显示出最小的异质性和不对称性,进一步支持研究结果的有效性.
结论:
- 门德尔的随机化分析支持儿童体重指数增加和患上牛皮的可能性更高之间的因果关系.
- 这些发现强调了在儿童时期保持健康的BMI的重要性,以潜在地预防牛皮.
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