系统性免疫炎症指数与儿童急性支气管炎的严重程度之间的关系
Ömer Furkan Kızılsoy1, Muhammet Furkan Korkmaz1, Gülsüm Elif Şenkan1
1Department of Pediatrics, University of Health Sciences, Bursa Faculty of Medicine, City Training and Research Hospital, Bursa, Turkey.
Laboratory medicine
|June 23, 2023
概括
系统性免疫炎症指数 (SII) 可以帮助评估儿童急性支气管炎 (AB) 的严重程度. 在严重的AB病例中观察到较高的SII值,这表明它作为疾病分层的生物标志物的有用性.
科学领域:
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 急性支气管炎 (AB) 是一种常见的儿童呼吸系统疾病,具有全球健康影响.
- 系统性免疫炎症指数 (SII) 正成为潜在的炎症生物标志物.
- 评估AB严重程度对于有效的患者管理至关重要.
研究的目的:
- 研究SII在评估儿科患者急性支气管炎的严重程度方面的实用性.
- 评估SII作为一种潜在的新一代炎症生物标志物,用于AB严重程度分层.
主要方法:
- 一项前性观察性研究包括74名被诊断为AB的儿科患者.
- 根据修改的Tal得分,患者被分为轻度,中度和严重的AB组.
- 分析了完整血清,C-反应蛋白,前素和SII. 使用接收器操作特征 (ROC) 分析来评估预测性能.
主要成果:
- 中性粒细胞数量,中性粒细胞与淋巴细胞的比率和SII随着AB重度的增加而显著升高.
- 红细胞分布宽度在中度AB组中较高.
- 在ROC分析中,SII在区分严重的AB病例方面显示了曲线下的最高面积.
结论:
- 患有AB入院的儿科患者在严重疾病组中表现出显著更高的SII值.
- 在患有急性支气管炎的儿童中,SII可能成为额外严重程度分层的宝贵工具.
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