新型全身疗法的采用:在患有晚期非小细胞肺癌的成年人中,现实世界的模式
Nikki M Carroll1, Jennifer Eisenstein2, Andrea N Burnett-Hartman3
1Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA.
Cancer treatment and research communications
|June 23, 2023
概括
晚期非小细胞肺癌 (NSCLC) 的全身治疗已经转向免疫疗法. 随着时间的推移,越来越多的患者正在接受一线和二线治疗,特别是免疫治疗.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 癌症治疗方法 癌症治疗方法
背景情况:
- 晚期非小细胞肺癌 (NSCLC) 的全身治疗正在从传统化疗转向新的免疫疗法和向疗法.
- 临床试验显示,使用这些新型药物的生存率有所提高,因此需要对其利用的真实数据.
研究的目的:
- 检查在社区实践环境中使用系统疗法的趋势,以治疗 de novo 第四期非小细胞肺癌 (NSCLC).
- 评估在一线和二线环境中基于免疫疗法治疗的日益普及情况.
主要方法:
- 在四个医疗保健系统中,对1442名新诊断的第四阶段NSCLC患者的回顾性分析,这些患者在2012年3月至2020年12月期间被诊断出患有NSCLC.
- 描述患者的特征和治疗模式,包括一线和二线全身疗法. 使用流行率来估计相关性.
主要成果:
- 接受任何一线全身治疗的患者比例从2012年的53%增加到2020年的71%
- 在研究期间,第一线免疫疗法 (有或没有化疗) 的使用率显著从14%上升到66%.
- 接受二线免疫治疗的患者比例也从13%大幅增加到37%.
结论:
- 随着时间的推移,系统治疗的整体使用量显著增加,高级NSCLC患者的免疫治疗使用量急剧增加.
- 需要进一步的研究才能充分了解这些不断变化的治疗模式的短期,长期和财务影响.
更多相关视频
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.5K
08:52Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
Published on: November 22, 2021
4.1K
相关概念视频
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:49Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K