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热预调可以减少手术内获得的压力损伤的发生率

Ping Hou¹, Huiping Xue², Shuwen Chang³

¹Nagano College of Nursing, 399-4117, Nagano, Japan; School of Nursing and School of Public Health, Yangzhou University, 225000, Yangzhou, China.

Journal of thermal biology

|June 23, 2023

概括

热预调 (TPC) 在手术患者和老鼠中显著减少了手术内获得的压力损伤 (IAPI). 这种保护作用与热冲击蛋白27 (HSP27) 的表达增加有关,这表明TPC是一种有前途的预防策略.

科学领域:

生物医学工程生物医学工程
皮肤病学皮肤病学
手术创新在外科创新.

背景情况:

术内获得的压力损伤 (IAPI) 是漫长的外科手术过程中常见的并发症.
已知热冲击蛋白 (HSP) 能够保护皮肤组织免受压力引起的损伤.

研究的目的:

为了研究热预调 (TPC) 对手术患者和老鼠的IAPI的预防作用.
为了识别对TPC的反应中差异表达的HSP基因.

主要方法:

动物模型:无毛大鼠在压力损伤诱导之前接受了TPC. 皮肤病变大小和HSP表达 (mRNA/蛋白质) 用RT-PCR,西斑和免疫组织化学测量.
人类研究:118名手术患者被随机分配到TPC和对照组. 监测了圣器皮肤温度,压力和IAPI发生率.

主要成果:

在大鼠中,TPC显著降低了IAPI的大小和发病率.
TPC在老鼠皮肤中增加了HSP27mRNA和蛋白质表达,HSP27局部化在皮肤和基底细胞中.
人类研究显示,与对照组相比,TPC组的IAPI减少了75%.

结论:

在动物模型和人类手术患者中,TPC有效地减少了IAPI的发生率.
提高HSP27的监管是TPC对IAPI的保护机制的一个关键因素.
需要进一步的研究来阐明HSP27介导的压力损伤预防的分子机制.

关键词:

选择性手术是可以选择的.热冲击蛋白质是一种热冲击蛋白质.在手术过程中获得的压力损伤.压力损伤的压力损伤.热预先调节热预先调节

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