产妇劳动,外周止痛和后代自闭症特征之间的关联
Ming Ann Sim1, Liang Shen2, Lian Kah Ti3
1National University Hospital, Department of Anesthesia, Singapore.
Journal of clinical anesthesia
|June 23, 2023
概括
在长达7年的随访期间,孕产妇外围止痛 (MEA) 与自闭症谱系障碍 (ASD) 或后代的自闭症特征没有显著联系. 这项研究提供了关于MEA和神经发育结果的关键数据.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 产科 产科 产科 产科 产科
背景情况:
- 有矛盾的证据表明,母体外围止痛 (MEA) 和自闭症谱系障碍 (ASD) 之间存在关联.
- 以前的研究往往缺乏对后代自闭症特征的前性神经行为评估.
- 需要强大的纵向数据来澄清这种关系.
研究的目的:
- 为了前性地研究MEA和后代自闭症特征之间的关联.
- 为了评估MEA暴露后ASD诊断和亚临床自闭症特征的风险.
- 为临床实践和家长咨询提供基于证据的信息.
主要方法:
- 进行了一项前性神经行为观察队列研究.
- 单体,非试管婴儿在36周怀孕后通过正常阴道分娩出生的孩子被招募.
- 后代被跟踪了7年,评估包括社会反应量表 (SRS) 和神经行为电池.
主要成果:
- 在7年内,MEA和异常SRS得分之间没有发现显著的关联 (OR 0.726,p=0.305).
- 在人口调整后,MEA暴露与其他自闭症特征评估中的异常得分没有显著关联.
- 在暴露于MEA和未暴露组之间,ASD诊断的发生率没有显著差异 (2.32%对1.76%,p=0.506).
结论:
- 在7年的时间里,母亲的外周止痛与ASD或子孙的自闭症特征的发展没有显著的关联.
- 这些发现表明,MEA不太可能是ASD的主要风险因素.
- 由于广泛的置信区间和当前的队列大小,需要对更大的队列进行进一步的研究.
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