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微生物组对抗生素耐药性和病原性消除中的毒性因子控制的界面机制的识别,通过功能化的微泡来消除病原性

Ming Zhang¹, Beilei Yu¹, Qunkai Fang¹

¹Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China.

|June 23, 2023

概括

病毒性因素显著影响了使用修改后的微泡从废水中去除抗生素耐药和致病细菌. 了解这些因素是改善水处理技术和防止病原体传播的关键.

科学领域:

环境科学环境科学
微生物学微生物学
水处理技术水处理技术

背景情况:

全球流行病引发了人们对病原体和抗生素耐药细菌污染水的担忧.
传统的废水处理方法可能无法完全消除这些污染物.
病毒性因子 (VFs) 在细菌生存和致病性方面发挥着至关重要的作用.

研究的目的:

研究毒性因子如何影响废水中抗生素耐药和致病细菌的去除.
评估无臭氧或封装在臭氧中的Fe (III) 凝固剂修饰的合体微气泡 (O3_free-CCMBs或O3-CCMBs) 在去除这些细菌方面的有效性.
了解细菌被微泡捕获和失活的机制.

主要方法:

使用的没有臭氧的合体微气泡 (O3_free-CCMBs) 和封装着臭氧的合体微气泡 (O3-CCMBs),经过Fe (III) -凝固剂的修改.
采用微生物组测序分析来评估细菌去除效率.
研究了特定毒性因子 (粘附性,运动性) 和细菌细胞结构对微泡性能的影响.

主要成果:

O3_free-CCMB的性能受到细菌毒性表型的显著影响,特别是与粘附相关的增强细胞捕获的VF.
与机动性相关的VF可以阻碍初始捕获,但被O3-CCMB诱导的氧化损伤所克服.
细胞膜结构 (外流) 和溶解的有机物影响了微泡捕获和氧化效率.

结论:

封装在臭氧中的微气泡有望减少废水中抗生素耐药性和病原性传播.
病毒性特征是微泡治疗性能的关键决定因素.
需要进一步研究和提高人们对毒性因素对水处理效率的影响的认识.

关键词:

抗生素耐药的细菌可以抵抗抗生素.功能化的合体微气泡.微生物组的测序方法致病性细菌是一种致病性细菌.病毒性因素是病毒性因素.

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