涉及西拉的致命过量服用和局部地理聚类:库克县,伊利诺伊州,2019-2022年
Chris Delcher1, Nicholas Anthony1, Mojde Mir2
1College of Pharmacy, Department of Pharmacy Practice and Science, University of Kentucky, United States; Institute for Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Kentucky, United States.
Drug and alcohol dependence
|June 23, 2023
概括
在非法供应中发现的一种兽医药物Xylazine与库克县致命的过量服用有关. 这些过量用药地点显示局部集群,特别是在芬太尼,有助于针对性减少危害的战略.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 空间分析 空间分析
背景情况:
- 兽医镇静剂西拉在美国各地的非法药物供应中越来越多地被检测到.
- 在致命的过量服用中,它的存在是一个日益严重的公共卫生问题,需要进行地理分析以了解分布模式.
- 伊利诺伊州库克县是伊利诺伊州在其非法药物市场中报告了西拉的州之一.
研究的目的:
- 为了在伊利诺伊州库克县地理上分析涉及西拉致命过量剂的空间分布.
- 为了确定与克西拉有关的过量死亡的潜在集群.
- 为了比较涉及西拉过量剂的空间模式与涉及其他物质 (如芬太尼,酒精和兴奋剂) 的空间模式.
主要方法:
- 利用了库克县医学检查官办公室 (CCMEO) 从2019年1月1日到2022年6月30日的公开数据.
- 采用里普利的K函数来评估与对照组相比,病例聚类的可能性 (克西拉负过量).
- 应用了伯努利空间扫描统计数据,以确定涉及西拉致命过量剂的特定地理集群.
主要成果:
- 几乎所有的 (94.4%) 克西拉阳性致命过量也涉及芬太尼.
- 涉及西拉过量事件显示局部集群,最大距离为10.6英里.
- 空间扫描分析揭示了与酒精和兴奋剂共用相比的高风险集群和与芬太尼尔共用相比的低风险集群.
结论:
- 致死性过量使用西拉的地点表现出局部集群,特别是与芬太尼过量使用有关.
- 虽然精确的集群检测在分析的尺度上是有限的,但研究结果为社区层面的减少危害策略提供了洞察力.
- 了解这些空间模式对于有效地针对干预和资源来应对西拉危机至关重要.
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