在佐皮克隆的影响下驾驶:在两个连续的血液样本之间消除
Maren Cecilie Strand1, Øyvind Bleka1, Lena Kristoffersen1
1Department of Forensic Medicine, Oslo University Hospital, Oslo, Norway.
Forensic science international
|June 23, 2023
概括
佐皮克隆在被捕的司机中很常见,通常与其他药物一起使用. 这项研究估计了佐皮克隆.
科学领域:
- 法医毒理学 法医毒理学
- 药理动力学 药理动力学
- 临床化学 临床化学
背景情况:
- 佐皮克隆是一种在被逮捕的司机中经常检测到的催眠药物.
- 年龄和药物相互作用等因素可以影响佐皮克隆的消除半衰期 (t1/2).
- 了解佐皮克隆的t1/2对于法医病例评估至关重要.
研究的目的:
- 为了确定被逮捕的司机中佐皮克隆度和同时摄入的药物.
- 使用连续血液样本调查佐皮克隆的消除半衰期 (t1/2).
主要方法:
- 在被捕司机的血液样本中分析佐皮克隆度 (2003-2021年).
- 使用LC-MS或UHPLC-MS/MS.确定佐皮克隆水平.
- 根据20-60分钟间隔收集的两个连续血液样本中的度变化,估计t1/2,假设第一阶动力学.
主要成果:
- 在2401名被捕的司机中检测到佐皮克隆,中位数度为0.044 mg/L.
- 常见的共同摄入物质包括乙醇 (36%),甘 (22%),安非他胺 (14%) 和THC (14%).
- 在血度下降的情况下,索皮克隆的估计明显消除t1/2从3.1到3.8小时不等.
结论:
- 佐皮克隆在被捕的司机中经常被发现,通常在超治疗度和与其他物质结合.
- 在这个人群中,佐皮克隆的明显消除半衰期约为3.13.8小时.
- 这些发现与以前报告的健康个体半衰期的下端一致.
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