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Updated: Jul 25, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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评估作为人类ClpP激动剂的二甲基胺化合物的结构活性关系和抗白血病活性

Ranran Zhang1, Pengyu Wang1, Bingyan Wei2

  • 1School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China; State Key Laboratory of Drug Research, Centre for Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

European journal of medicinal chemistry
|June 23, 2023
PubMed
概括

一种新的化合物,ZG36,作为人体类蛋白酶P (ClpP) 的强有力的激动剂,有效降解急性髓性白血病 (AML) 细胞中的线粒体蛋白质. 这种向性降解导致白血病细胞死亡,并在临床前模型中抑制瘤生长.

关键词:
抗白血病治疗的治疗方法这种药物是ClpP激动剂.线粒体呼吸链中的线粒体呼吸链.结构与活动的关系.

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