自杀行为中的HPA轴基因与创伤暴露之间的基因与环境相互作用:系统性审查
Thelma Beatriz González-Castro1, Isela Esther Juárez-Rojop2, Carlos Alfonso Tovilla-Zárate3
1División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco, United Mexican States.
Journal of psychiatric research
|June 23, 2023
概括
创伤暴露和特定的HPA轴基因与自杀行为 (SB) 有着显著的联系. 本系统性审查强调了基因与环境的相互作用,特别是在SB开发中的CRHR1和FKBP5.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 自杀行为 (SB) 源于复杂的基因环境相互作用.
- 创伤事件和遗传因素与SB有关.
- HPA轴基因在SB易感性中的作用需要进行系统的调查.
研究的目的:
- 系统地审查有关创伤暴露,HPA轴基因和SB之间的联系的现有证据.
- 确定特定的HPA轴基因参与基因环境相互作用,有助于SB.
- 综合有关这一主题的流行病学研究的发现.
主要方法:
- 在主要科学数据库 (PubMed,EBSCO,Science Direct,PsychInfo,Scopus) 进行系统的文献搜索,直到2022年2月.
- 包括13项流行病学研究,包括11,756名受试者.
- 分析的重点是研究儿童和终身创伤暴露与SB和基因环境相互作用相关的研究.
主要成果:
- 所有包括的研究都报告了创伤暴露和SB之间的积极关联.
- 在CRHR1,CRHR2,FKBP5和CRHBP基因中确定了基因与环境的相互作用.
- 对于CRH,NR3C1,MC2R和POMC基因,没有发现对SB的显著基因环境影响.
结论:
- 创伤暴露是一种潜在的机制,将HPA轴基因活性与SB联系起来.
- 特定的HPA轴基因 (CRHR1,FKBP5) 在SB发育中与创伤相互作用.
- 对基因与环境相互作用的进一步研究对于理解和预防SB至关重要.
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