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在炎症性肠道疾病中对萨尔科佩尼亚进行系统审查
Hala Fatani1, Adina Olaru2, Rebecca Stevenson3
1The Nottingham Digestive Diseases Centre (NDDC), School of Medicine, University of Nottingham, Nottingham, UK; MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research & National Institute of Health Research, Nottingham Biomedical Research Centre, University of Nottingham, UK.
超过三分之一的成人炎症性肠病 (IBD) 患者患有肌或前,近五分之一患有. 这种肌肉损失与IBD治疗失败和并发症的增加有关.
科学领域:
- 胃肠道学和肝病学
- 营养科学 营养科学
- 老年病的医生 老年病的医生
背景情况:
- 炎症性肠病 (IBD) 越来越多地与肌肉缩和肉症有关.
- 了解IBD中肉类的患病率和影响对于患者管理至关重要.
研究的目的:
- 为了估计IBD患者的肉症患病率.
- 为了研究萨尔科佩尼亚对IBD患者结局的影响.
- 评估营养干预对IBD肌肉质量和力量的有效性.
主要方法:
- 对成年IBD患者的同行评审研究 (RCT,非RCT,观察性) 的系统审查.
- 包括到2021年7月28日发表的研究.
- 定义了低肌肉质量/强度,肉症并发症和营养干预效应的标准.
主要成果:
- 42%的成年IBD患者患有肌,34%患有前,17%患有.
- 在IBD中肌显著与治疗失败,手术风险增加,住院和术后并发症有关.
- 营养干预措施,特别是高蛋白饮食计划,显示出改善IBD患者肌肉质量的潜力.
结论:
- 很大一部分成年IBD患者患有肌和肉,影响疾病的结果.
- 在IBD中 Sarcopenia 与治疗失败,手术风险和骨矿物质密度降低有关.
- 需要进一步研究标准化定义和前性研究,包括用于营养干预的RCT,以澄清萨科佩尼亚在IBD中的作用和管理.
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