在精神分裂症的电治疗中,炎症和 kynurenine 途径代谢物之间的关联:对临床疗效的影响
Yu Wang1, Xinyu Fang1, Guangfa Wang2
1Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
精神分裂症患者表现出改变的 kynurenine 途径 (KP) 代谢物和炎症. 电治疗 (ECT) 在精神分裂症中的有效性与炎症有关,较低的炎症与更好的临床结果和KP代谢物调节有关.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 三丰代谢的 kynurenine 途径 (KP) 涉及到精神分裂症的发病.
- 免疫系统与KP的相互作用可能在精神分裂症中起作用.
研究的目的:
- 在精神分裂症患者中调查炎症,KP代谢物和电疗法 (ECT) 疗效之间的关系.
- 探索炎症子组如何影响治疗对ECT的反应.
主要方法:
- 招募了28名精神分裂症患者和25名健康对照人群,将他们分成炎症子组.
- 在ECT前,期间和之后测量了细胞因子基因表达和血KP代谢物.
- 分析了使用PANSS分数和MoCA的认知功能的临床改善.
主要成果:
- 与对照组相比,精神分裂症患者的KP代谢物水平发生了变化,IL-18mRNA水平更高.
- 患有较低炎症的患者在ECT后获得了更好的临床改善,特别是在负面症状方面.
- ECT降低了IL-18mRNA;KYN/TRP和KYNA/TRP仅在低炎症患者中显著降低.
- 基线IL-18与KP代谢物和负症状相关;基线TRP和XA与PANSS相关.
结论:
- 炎症和KP之间的相互作用对精神分裂症中ECT的机制至关重要.
- 炎症状态影响ECT对KP的调节,影响临床疗效.
- 向炎症和KP代谢可能会提高精神分裂症患者的ECT结果.
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