与代谢相关的脂肪肝疾病的原血栓性倾向
Dawn Swan1, Ton Lisman2, Armando Tripodi3
1Department of Haematology, Beaumont Hospital, Dublin, Ireland.
Journal of thrombosis and haemostasis : JTH
|June 23, 2023
概括
肝病,特别是代谢相关的脂肪肝病 (MAFLD),与凝血风险增加有关. 这篇评论探讨了MAFLD.
科学领域:
- 肝病学和血栓形成
背景情况:
- 关于肝脏功能的历史观点已经从占卜演变为理解肝脏在消化和排毒中的作用.
- 以前,肝病仅与出血风险有关,但目前的证据突出显示了血栓潜在的增加.
- 与代谢相关的脂肪肝疾病 (MAFLD) 正在增加,可能很快成为肝移植的主要原因.
研究的目的:
- 审查肝病,特别是MAFLD和血栓塞栓事件之间的关联.
- 检查抗凝血剂在晚期肝病中的安全性和有效性.
- 探索抗血栓剂在缓解MAFLD纤维化进展中的潜力.
主要方法:
- 关于肝病和血栓塞栓症的研究的文献综述.
- 对晚期肝病患者抗凝血药物的证据分析.
- 讨论对MAFLD纤维化抗血栓治疗的研究.
主要成果:
- 越来越多的证据将肝病,包括MAFLD,与动脉和静脉血栓栓塞性疾病联系在一起.
- 晚期肝病的抗凝血药物存在复杂的安全性和有效性考虑.
- 抗血栓剂在减缓MAFLD纤维化中的潜在作用需要进一步研究.
结论:
- MAFLD是一个新兴的问题,与显著的血栓形成风险有关.
- 对于患有晚期肝病和血栓栓塞风险的患者,需要仔细考虑抗凝药.
- 对抗血栓策略的进一步研究可能为管理MAFLD进展提供新的途径.
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