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适度降低功能和年轻成年人的不良结果之间的关联:回顾性,基于人口的队列研究
Junayd Hussain1,2, Nicholas Grubic2, Ayub Akbari3
1School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
概括
估计的淋巴细胞过率 (eGFR) 适度下降与不良结果有关,特别是在年轻人中. 建议对年轻人的功能进行早期监测,以预防慢性病.
科学领域:
- 科和公共卫生
- 慢性病的流行病学 慢性病的流行病学
背景情况:
- 慢性病 (CKD) 是一个日益严重的公共卫生问题.
- 早期发现功能下降对于及时干预至关重要.
- 对于功能来说,特定于年龄的参考范围可能会影响风险评估.
研究的目的:
- 调查估计膜过率 (eGFR) 和不良健康结果之间的适度降低之间的特定年龄关联.
- 为了确定年轻人是否与老年人相比,与EGFR下降相关的风险不同.
主要方法:
- 基于人口的回顾性队列研究,使用加拿大安大略省链接的医疗保健行政数据集.
- 包括没有先前病史的成年居民 (18-65岁).
- 对EGFR值和组合不良结果 (死亡率,心血管事件,功能衰竭) 的分析,按年龄组 (18-39岁,40-49岁,50-65岁) 分层,相对于特定年龄的EGFR参考值.
主要成果:
- 在不同年龄组的17-18.8%的成年人中观察到适度的eGFR降低.
- 在所有EGFR类别中,年轻成年人 (18-39岁) 的不良结果与老年人相比,在年轻成年人 (18-39岁) 中始终更高.
- 对于适度的EGFR降低 (70-80毫升/分钟/1.73米2),年轻成年人 (1.42) 的不良结果危险比率明显高于老年人 (1.13-1.08).
结论:
- 轻微的eGFR下降与不良结果的增加率有关,特别是在年轻人中.
- 在年轻个体的EGFR水平低于80mL/min/1.73m2时,观察到对不良结果的相对风险更高.
- 研究结果支持在年轻人中加强功能监测,以促进早期识别有风险的个体,并预防CKD的进展.
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