维生素D状况和慢性阻塞性肺病风险:英国生物库前性研究
Zheng Zhu1, Xinglin Wan2, Jiannan Liu3
1Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
BMJ open respiratory research
|June 23, 2023
概括
低维生素D (25(OH) D水平与较高的慢性阻塞性肺病 (COPD) 风险和死亡率有关. 这项大型的英国生物库研究揭示了显著的反向关联,突出了维生素D.
科学领域:
- 肺部医学 肺部医学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 维生素D缺乏与炎症性疾病有关,但其在COPD中的作用仍在争论中.
- 之前对维生素D和COPD的研究已经产生了相互矛盾的结果.
- 这项研究调查了血清25-基维生素D (25(OH) D) 与COPD风险和存活率之间的联系.
研究的目的:
- 为了检查血清25(OH) D水平与患上COPD的风险之间的关联.
- 评估COPD患者血清25(OH) D度与生存率之间的关系.
- 探索潜在的剂量反应关系,并根据性别和吸烟状况对效果进行修改.
主要方法:
- 利用了英国生物库数据,从最初没有COPD的403,648名参与者.
- 采用多变量调整的考克斯回归模型来分析25~OH) D和COPD发病率/死亡率之间的关联.
- 适用于剂量反应分析的受限立方线和生存曲线的Kaplan-Meier.
主要成果:
- 在25OH) D水平和COPD风险之间发现了非线性反向关联.
- 与第四个五分位数相比,25...OH) D水平最低的参与者患COPD的风险增加了23%.
- 最低的25...OH) D水平与COPD患者全因死亡风险增加38%有关,男性和吸烟者的影响更强.
结论:
- 血清25(OH) D度与COPD发病率和死亡率相反相关.
- 维生素D可能在COPD的发展和进展中起到保护作用.
- 保持足够的维生素D水平可能是预防和治疗COPD的潜在策略.
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