在移植和细胞治疗急性白血病的皮肤学并发症
Shahab Babakoohi1, Stephanie L Gu2, Hamid Ehsan1
1Levine Cancer Institute, Atrium Health Wake Forest Baptist, Charlotte, NC, USA.
Best practice & research. Clinical haematology
|June 23, 2023
概括
造血干细胞移植和CAR-T细胞疗法改善了白血病的治疗,但可能导致皮肤问题. 本综述涵盖了管理这些常见的皮肤瘤学不良事件.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 采用细胞免疫疗法,包括造血干细胞移植 (HSCT) 和CAR-T细胞疗法,已经改变了急性白血病的治疗方法.
- 这些先进的疗法为白血病患者提供了改善的疾病反应和生存率.
- 然而,接受这些治疗的患者容易发生各种不良事件.
研究的目的:
- 审查接受采用细胞疗法的患者常见皮肤不良事件的诊断和管理.
- 突出支持性皮病学在治疗相关皮肤毒性的管理中的作用.
- 为管理正在接受细胞治疗的白血病患者的临床医生提供全面的概述.
主要方法:
- 文献综述总结了与HSCT和CAR-T细胞疗法相关的皮肤毒性现有知识.
- 分析常见的不良事件,包括药物突发症,移植与宿主疾病以及瘤/瘤副瘤并发症.
- 对这些皮肤学并发症的诊断和管理策略的综合.
主要成果:
- 细胞疗法可以导致由于化疗条件,移植,细胞因子释放综合征和维持疗法的各种皮肤毒性.
- 常见的不良事件包括药物喷发,移植与宿主疾病 (GVHD),以及较少发生的瘤和副瘤皮肤并发症.
- 有效的管理策略对于患者的福祉和治疗坚持至关重要.
结论:
- 在接受白血病细胞治疗的患者中,支持性皮肤瘤学对于管理皮肤毒性至关重要.
- 早期识别和适当管理皮肤不良事件可以改善患者的结果和生活质量.
- 需要进一步的研究和专业护理,以优化在采用细胞免疫治疗中的皮肤病学支持.
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