血型造血干细胞移植中的药物基因组学:对支持疗法和调节方案的影响
Sarah A Morris1, D Grace Nguyen1, Jai N Patel1
1Department of Cancer Pharmacology & Pharmacogenomics Levine Cancer Institute, Atrium Health, 1021 Morehead Medical Drive, Charlotte, NC, 28204, USA.
Best practice & research. Clinical haematology
|June 23, 2023
概括
药物基因组测试可以通过个性化药物选择来改善所有原性造血干细胞移植患者的结果. 这种方法有助于管理毒性和并发症,增强患者护理和降低风险.
科学领域:
- 血液学 血液学 血液学
- 药物基因组学 药物基因组学
- 移植医学 移植医学
背景情况:
- 全基性造血干细胞移植 (HSCT) 已经减少了死亡率.
- 管理与治疗相关的毒性和移植后并发症仍然是一个重大的临床挑战.
- 药物代谢和反应的个体间变化会影响治疗的有效性和安全性.
研究的目的:
- 审查在HSCT中药基因组测试的临床应用.
- 突出药物基因组策略,以优化HSCT患者的药物治疗.
- 讨论关于药物基因组学在调节方案中的新兴证据.
主要方法:
- 在HSCT中临床药物基因组应用的文献综述.
- 对抗真菌药物,免疫抑制剂和支持性护理中的药物基因组学证据的总结.
- 包括与调节方案相关的新兴药物基因组数据.
主要成果:
- 药物基因组测试有可能减轻HSCT中不良药物反应.
- 基于遗传特征的个性化药物选择可以改善结果.
- 证据支持对抗真菌药物,免疫抑制剂和支持性护理的药物遗传学指导.
结论:
- 药物基因组学是优化HSCT患者管理的宝贵工具.
- 通过药物基因组测试量身定制药物治疗可以减少毒性并改善生存率.
- 需要进一步研究HSCT调节方案中的药物遗传学应用.
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