长度灰色物质轨迹在儿科轻度创伤性脑损伤中
Ashley L Ware1, Catherine Lebel2, Adrian Onicas2
1From the Department of Psychology (A.L.W.), Georgia State University, Atlanta; Department of Neurology (A.L.W.), University of Utah, Salt Lake City; Departments of Psychology (A.L.W., A.O., K.O.Y.) and Radiology (C.L., B.G.G.), Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; Computer Vision Group (A.O.), Sano Centre for Computational Medicine, Kraków 30-054, Poland; Department of Radiology (N.A.), University of Ottawa, Children's Hospital of Eastern Ontario Research Institute; Department of Psychology (M.H.B.), University of Montreal & CHU Sainte-Justine Hospital Research Center, Québec; Department of Biomedical Engineering (C.B.), University of Alberta, Edmonton; Division of Neurology (B.H.B.), Department of Pediatrics, University of British Columbia and BC Children's Hospital Research Institute, Vancouver; University of Alberta and Stollery Children's Hospital (W.C.), Edmonton; Department of Radiology (M.D.), Radio-oncology and Nuclear Medicine, Institute of Biomedical Engineering, University of Montreal; CHU Sainte-Justine Research Center, Québec; Department of Pediatrics (Q.D.), University of British Columbia, BC Children's Hospital Research Institute, Vancouver; CHU Sainte-Justine Research Center (S.D.), Department of Radiology, Radio-oncology and Nuclear Medicine, University of Montreal, Québec; Departments of Pediatrics and Emergency Medicine (S.B.F.), Cumming School of Medicine, University of Calgary, Alberta; Department of Pediatric Emergency Medicine (J.G.); CHU Sainte-Justine, Department of Pediatrics, University of Montréal, Québec; Children's Hospital of Eastern Ontario Research Institute (A.-A.L., R.Z.); Department of Cellular and Molecular Medicine (A.-A.L.) and Pediatrics and Emergency Medicine (R.Z.), University of Ottawa; and Department of Pediatrics and Emergency Medicine (R.Z.), University of Ottawa, Children's Hospital of Eastern Ontario Research Institute, Canada. alware@gsu.edu.
在儿童中,轻度创伤性脑损伤 (mTBI) 可以改变典型的脑灰质稀释,直至受伤后的六个月. 这些变化凸显了在评估儿科脑损伤时需要考虑神经发育因素的必要性.
科学领域:
- 神经科学是一个神经科学.
- 儿科神经学 儿科神经学
- 放射学 放射学是一门学科.
背景情况:
- 儿科轻度创伤性脑损伤 (mTBI) 是常见的,但其对大脑结构的长期影响尚未完全理解.
- 了解灰质宏观结构的变化对于诊断和管理儿科头部损伤至关重要.
研究的目的:
- 为了检查儿童轻度创伤性脑损伤 (mTBI) 后大脑灰质宏观结构的轨迹.
- 为了研究像伤害后的时间,年龄,性别和症状持续性等因素如何影响这些结构变化.
主要方法:
- 一项前性的纵向队列研究,涉及8至16.99岁的患有mTBI或轻度骨科损伤 (OI) 的儿童.
- T1加权的MRI扫描是在伤害后的急性 (2-33天) 和慢性 (3或6个月) 后获得的.
- 使用自动细分来导出宏观结构指标,并使用线性混合效应模型进行分析.
主要成果:
- 在mTBI和OI组之间,没有观察到大脑总体,白质或灰质体积的显著差异.
- 与对照人群相比,mTBI患者在特定区域 (例如,角,基本前脑) 慢性出现皮层稀释,根据年龄和性别调节.
- 持续的症状与前和后区域皮质稀薄模式的改变有关,特别是在男性和年幼儿童中.
结论:
- 后急性灰色物质宏观结构在儿科mTBI中具有有限的诊断和预后效用.
- mTBI会破坏皮质灰质稀释的典型过程,长达六个月,不论症状是否消失.
- 神经生物学的异质性需要在神经发育框架内检查与临床结果相关的大脑结构.
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