在2型糖尿病中血糖危险指数 (GRI) 和糖尿病视网膜病变之间的关联:一个队列研究
Yaxin Wang1, Jingyi Lu1, Jiaying Ni1
1Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Diabetes, obesity & metabolism
|June 23, 2023
概括
较高的血糖危险指数 (GRI) 与2型糖尿病患者糖尿病视网膜病变 (DR) 风险增加有关. 这种复合度量可能有助于预测DR发展.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 代谢综合征是代谢综合征的一种.
背景情况:
- 糖尿病视网膜病变 (DR) 是导致2型糖尿病视力丧失的主要原因.
- 当前的标志物可能无法完全捕捉DR发展的风险.
- 一个新的复合度量,血糖危险指数 (GRI) 已被提出.
研究的目的:
- 研究2型糖尿病成年人血糖危险指数 (GRI) 与糖尿病视网膜病变 (DR) 发生率之间的关联.
主要方法:
- 一组1204名患有2型糖尿病且没有基线DR的成年人被跟踪了8.4年的中位数.
- 葡萄糖血风险指数 (GRI) 是从连续血糖监测数据计算出来的.
- 考克斯比例危险回归被用来分析GRI和事件DR之间的关联.
主要成果:
- 在随访期间,301名患者发展了DR.
- 较高的GRI四分位数与发生DR的风险增加有关 (HRs从1.05到1.53).
- 每次GRI的1-SD增加都与DR风险增加20%有关 (HR1.20,95%CI1.07-1.33).
结论:
- 血糖危险指数 (GRI) 的升高与2型糖尿病中患糖尿病视网膜病变的风险更高有关.
- GRI显示出作为预测DR风险的有价值的临床工具的潜力.
- 需要进一步的研究来验证GRI的临床实用性.
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