在接受免疫抑制药物治疗的个体中使用HepB-CpG疫苗接种疫苗
Robert Perrillo1, Luis Felipe Garrido1, Tsung-Wei Ma2
1Hepatology Division, Baylor Scott and White Medical Center, Dallas, TX, United States.
Vaccine
|June 23, 2023
概括
免疫辅助的乙型肝炎疫苗 (HepB-CpG) 在70%的免疫抑制患者中达到血清保护性抗体水平. 这种疫苗有望改善弱势群体的HBV疫苗接种结果.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 免疫抑制的个体往往对传统的复合性乙型肝炎疫苗表现出不理想的反应.
- 乙型肝炎病毒 (HBV) 疫苗接种对这一群体来说至关重要,以预防感染.
研究的目的:
- 评估FDA批准的免疫辅助HBV疫苗 (HepB-CpG) 在医学上免疫抑制患者的疗效.
- 评估接受生物药物或抗拒治疗的患者的抗体反应.
主要方法:
- 一组10名免疫抑制患者在0周和4周接受了HepB-CpG疫苗.
- 在第12周,如果抗HBs水平低于10mIU/mL,则给予第三剂.
- 参与者包括那些使用生物药物和抗排斥疗法的人.
主要成果:
- 到第24周,70%的参与者达到血清保护性抗HBs水平 (≥10mIU/mL).
- 接受生物药物治疗的患者与接受抗拒治疗的患者相比,表现出更快的抗体反应.
- 移植个体通常需要接种第三剂疫苗才能达到足够的抗体水平.
结论:
- 免疫辅助的HepB-CpG疫苗在免疫抑制患者中显示出70%的血清保护率.
- 在接受生物药物治疗的患者中观察到更快的抗体发育.
- 补充疫苗在移植参与者中改善了抗体反应,这突显了它对这一亚组的重要性.
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