双极性障碍多基因风险的发育表现从婴儿期到中儿童期的双极性障碍
Ragna Bugge Askeland1,2,3, Laurie J Hannigan4,5,6,7, Kevin S O'Connell8,9
1Department of Mental Disorders, Norwegian Institute of Public Health, 0473, Oslo, Norway. ragnabugge.askeland@fhi.no.
Translational psychiatry
|June 23, 2023
概括
双相情感障碍的遗传风险与儿童的行为和对立挑性困难有关. 这一发现有助于早期检测和干预与双相情感障碍风险相关的儿童行为特征.
科学领域:
- 儿童心理学 儿童心理学
- 精神病学遗传学 精神病学遗传学
- 发育神经科学的发展神经科学.
背景情况:
- 关于双相情感障碍的遗传倾向如何影响儿童发育,情绪和行为特征的知识有限.
- 早期识别有风险儿童对于及时干预和改善结果至关重要.
研究的目的:
- 调查双相情感障碍的多基因风险评分与儿童发育结果之间的关联.
- 确定这些关联是否在一般人群中的男孩和女孩之间存在差异.
主要方法:
- 利用了挪威母亲,父亲和儿童队列研究中的28001名儿童的数据.
- 计算了双相情感障碍的多基因风险评分,并分析了与母亲报告的从婴儿期到8岁的发育结果的关联.
- 在多组框架内使用线性回归模型,将性别作为分组变量.
主要成果:
- 在8岁时发现双相情感障碍多基因风险得分和行为困难 (β=0.041) 和对抗性挑战性困难 (β=0.032) 之间存在显著的关联.
- 观察到与5岁时的活动水平和8岁时仁慈的负面关联.
- 确定了与3岁时运动困难的积极关联,以及8岁时注意力不集中和过度活动的积极关联.
结论:
- 双相情感障碍的遗传风险与儿童时期的破坏性行为,特别是行为和反对性挑性困难有关.
- 这些发现突出了潜在的早期行为标志物,用于对双相情感障碍的遗传倾向.
- 这项研究强调了考虑遗传因素对于理解儿童行为发展的重要性.
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