在全球人类群体中,PSCA位点的共享单元类型上的积极选择的空间和时间多样性
Risa L Iwasaki1,2, Yoko Satta3,4
1Department of Evolutionary Studies of Biosystems, School of Advanced Science, SOKENDAI (The Graduate University for Advanced Studies), Hayama, Kanagawa, 240-0193, Japan.
Heredity
|June 23, 2023
概括
阳性选择针对亚洲和非洲的不同前列腺干细胞抗原 (PSCA) 类型,表明本地适应速度很快. 这种选择目标的转换反映了适应不同环境的能力.
科学领域:
- 人类进化遗传学人类进化遗传学
- 人口遗传学 人口遗传学
- 分子进化的分子进化.
背景情况:
- 持续的基因变异促进了当地快速适应环境变化.
- 前列腺干细胞抗原 (PSCA) 基因与局部遗传适应有关.
- 尽管哈普洛类型是共同的,但它们可以成为跨种群差异性选择的目标.
研究的目的:
- 调查选择在局部适应中的常态遗传变异中的作用.
- 在不同的人群中识别PSCA基因中积极选择的特定目标单元类型.
- 了解PSCA地点的选择事件的进化动态和时间.
主要方法:
- 在亚洲和非洲人群中分析哈普洛型的频率和模式.
- 二维位置频谱分析,以评估内部基变异性.
- 最新的共同祖先 (TMRCA) 分析的时间,以估计选择的开始.
- 大致贝叶斯计算 (ABC) 分析以估计选择系数.
主要成果:
- 不同的单元类型 (亚洲的C-C-A,非洲的C-A-G) 是PSCA基因的积极选择的目标.
- 这两种单元类型都起源于非洲以外的分散之前,在两个种群中都存在.
- 有证据表明,正在进行C-C-A和C-A-G类型的硬扫描,具有最小的内变异性.
- 积极选择的开始估计在3-55万年前 (kya) 之间,与人口的细分相吻合.
- 估计的选择系数高达~3%.
结论:
- 在PSCA位点的积极选择目标的空间和时间切换是持续选择的新特征.
- 这种切换机制可能能够快速适应不同的当地环境.
- 这些发现突显了人类通过选择在常态遗传变异上的适应的动态性质.
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