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靠近红外激活的抗癌 (((IV) 复合物直接以无氧的方式对生物分子进行光氧化

Zhiqin Deng^1,2, Huangcan Li^2,3, Shu Chen^1,2

¹Department of Chemistry, City University of Hong Kong, Hong Kong SAR, P. R. China.

Nature chemistry

|June 23, 2023

概括

新的基于的药物使用近红外光直接杀死癌细胞没有氧气,有效地准癌症干细胞和抑制瘤生长. 这种金属增强光氧化方法提供了一个有前途的新癌症治疗策略.

科学领域:

化学化学化学
生物医学工程生物医学工程
在瘤学瘤学.

背景情况:

传统的光动力学癌症疗法依赖于氧气和可见光,限制了它们在深层,低氧瘤中的有效性.
向癌症干细胞和克服缺氧是癌症治疗中的关键挑战.

研究的目的:

开发新的近红外激活 (IV) 光氧化剂,用于氧气独立的癌细胞清除.
为了研究金属增强光氧化直接生物分子损伤和癌症治疗的机制.

主要方法:

小分子 (IV) 复合物的合成和表征.
在癌症干细胞中评估细胞吸收,暗毒性和光毒性.
研究细胞内机制,包括生物分子氧化,氧化应激和pH破坏.
在体内研究以评估瘤生长抑制,转移抑制和免疫激活.

主要成果:

Pt(IV) 复合物在内质网膜中积聚,具有较低的暗毒性.
近红外辐射触发金属增强光氧化,直接氧化生物分子并诱导氧化应激.
治疗破坏了细胞内pH平衡,导致非经典的亡和有效的癌症干细胞消除.
在体内研究表明显著的瘤生长抑制,抑制转移,并激活免疫反应.

结论:

近红外激活的Pt(IV) 光氧化剂为癌症治疗提供了有效的,不依赖氧气的策略.
金属增强光氧化和细胞内pH值的破坏是消除癌细胞的关键机制.
这种方法显示出局部治疗,免疫激活和克服传统疗法的局限性的潜力.

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