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Updated: Jul 25, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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通过调节p53和CHK1稳定性,SCML2有助于瘤细胞抵抗DNA损伤

Qianqian Peng1,2, Xin Shi1,2, Dingwei Li1,2

  • 1Department of Radiation and Medical Oncology, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, PR China.

Cell death and differentiation
|June 23, 2023
PubMed
概括

在DNA损伤后,SCML2稳定,增强化疗耐药性. 它通过影响p53,CHK1和p21稳定性,在p53-阳性与p53-阴性癌症中起不同的作用.

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