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休息心率和反社会行为:一种门德尔的随机化研究
Lucy Karwatowska1, Leonard Frach2, Tabea Schoeler3
1Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK. lucy.karwatowska.18@ucl.ac.uk.
Scientific reports
|June 23, 2023
概括
低静止心率 (RHR) 与反社会行为 (ASB) 没有因果关系. 这项研究没有发现任何支持因果关系的遗传证据,这表明观察到的关联可能来自其他因素.
科学领域:
- 行为遗传学 行为遗传学
- 心血管生理学心血管生理学
背景情况:
- 观察性研究表明,较低的静止心率 (RHR) 和增加的反社会行为 (ASB) 之间存在联系.
- 这种关联的因果性仍然不清楚,可能存在混或反向因果关系.
- 了解这种关系对于开发有效的干预措施至关重要.
研究的目的:
- 使用遗传方法研究静止心率 (RHR) 和反社会行为 (ASB) 之间的因果关系.
- 区分直接的因果关系和潜在的混因素.
- 提供关于自主神经系统在ASB中的作用的强有力的证据.
主要方法:
- 使用了两个样本的门德尔随机化 (MR),多变量MR和链接不平衡得分回归 (LDSC).
- 采用了RHR,反社会行为 (ASB) 和心率变化 (HRV) 的大型全基因组关联研究 (GWAS) 数据集.
- 作为仪器变量,为RHR选择了全基因组显著的单核酸多态.
主要成果:
- 在单变量或多变量MR分析中,没有发现RHR和ASB之间的统计学上显著的因果关系.
- 连接不平衡得分回归 (LDSC) 显示,心率测量和ASB之间没有显著的遗传相关性.
- 灵敏度分析表明,这些发现在异质性,性和反向因果关系方面是可靠的.
结论:
- 根据RHR的指示,自主神经系统功能中的个体差异似乎不会直接导致ASB.
- 在之前的研究中观察到的RHR和ASB之间的关联可能归因于混因素或反向因果关系.
- 需要进一步的纵向研究来证实这些发现,在ASB干预中使用RHR时建议谨慎.
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